Table 1.

EMT transcription factors and their targets.

EMT-TF	Down-Regulated Expression	References	Up-Regulated Expression	References
SNAIL	E-cadherin Plakophilin-2 Claudin-4 Cytokeratins 17, 18, 19, 20 Gelsolin Occludin Integrins α3, α6, β4 Crumbs3	[46,47] [48] [48] [48] [48] [48,49,50,51] [52,53] [54]	Vimentin Claudin-11 MMP1 MMP2 MMP7 MT1-MMP Fibronectin Integrins α2, β1, β3	[55,56] [57] [56] [55,56,58] [56] [56] [56] [31,41,53]
SLUG	E-cadherin Occludin	[59,60] [50,61]	Vimentin Fibronectin	[60] [60]
TWIST1	E-cadherin α-catenin γ-catenin	[62,63,64] [62,63] [63]	N-cadherin Vimentin Smooth muscle actin Fibronectin Integrin α5	[64,65] [63,64,66] [62,63] [62,63] [67]
ZEB1	E-cadherin Occludin Crumbs3	[68,69] [70] [70]	N-cadherin Fibronectin Vimentin	[71] [71] [72]
ZEB2	E-cadherin α-catenin	[56,73] [73]	N-cadherin Vimentin MMP1 MMP2 MT1-MMP Fibronectin	[73] [56,74] [56] [56] [56] [56]