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. 2021 Jan 27;11(2):164. doi: 10.3390/biom11020164

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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LPS-Tolerant and LPS-Responding RAW 264.7 cells have distinct secretomes. Plotting of p-values of LR vs. Con against p-values of LT vs. Con confirms that only 19.3% of proteins have significantly modified secretion in both conditions (A). Of the proteins with significantly modified secretion in only LR cells, over half of the proteins have increased secretion (B). Of the proteins with significantly modified secretion in only LT cells, over half of the proteins have increased secretion (C). A comparison of the enrichment of proteins secreted by the LR and LT cells with significantly modified secretion shows that the majority of these proteins were significantly decreased following treatment (D).