Table 1.
Potential regulators of LPS tolerance. Proteins with enhanced secretion by LPS-Tolerant RAW 264.7 cells vs. control and LPS-Responding cells that have associations with cell survival along with associations with either protein metabolism, reactive oxygen species metabolism, or both. “Secreted” results include “Yes” for proteins shown previously to be secreted in mice, “Yes (related)” for proteins shown previously to be secreted in humans, or “Yes (exosome)” for proteins shown previously to be secreted in exosomes in humans.
| Uniprot | Protein Name | Entrez Gene Name | LT Enrichment/LR Enrichment | Secreted | Cell Survival | Protein Metabolism | Redox |
|---|---|---|---|---|---|---|---|
| P09671 | SOD2 | superoxide dismutase 2 | 3.7913 | Yes (exosome) | Yes | Yes | Yes |
| Q64337 | SQSTM1 | sequestosome 1 | 4.6730 | Yes (exosome) | Yes | Yes | Yes |
| P10923 | SPP1 | secreted phosphoprotein 1 | 2.3679 | Yes | Yes | Yes | Yes |
| Q62351 | TFRC | transferrin receptor | 4.7225 | Yes | Yes | No | Yes |
| P60710 | ACTB | actin beta | 3.6136 | Yes (related) | Yes | No | Yes |
| P99029 | PRDX5 | peroxiredoxin 5 | 5.3956 | Yes (related) | Yes | No | Yes |
| Q3TCH7 | CUL4A | cullin 4A | 1.9345 | Yes (exosome) | Yes | Yes | No |
| Q9CXW4 | RPL11 | ribosomal protein L7 | 1.1280 | Yes (exosome) | Yes | Yes | No |
| P46471 | PSMC2 | proteasome 26S subunit, ATPase 2 | 1.6182 | Yes (related) | Yes | Yes | No |
| P11438 | LAMP1 | lysosomal associated membrane protein 1 | 2.8676 | Yes (exosome) | Yes | Yes | No |
| P22777 | SERPINE1 | serpin family E member 1 | 2.2662 | Yes | Yes | Yes | No |
| P25085 | IL1RN | interleukin 1 receptor antagonist | 1.0980 | Yes | Yes | Yes | No |
| P41245 | MMP9 | matrix metallopeptidase 9 | 3.7096 | Yes | Yes | Yes | No |