Table 1.

Summary information of cancer GWAS samples and power assessment.

Cancer Type	Subtype	N Cases	N Controls	SNP Set	Minimum Detectable OR
Pancreatic cancer	overall	7110	7264	UGT1A1 SNP	1.12/0.89
				Non-UGT1A1 SNPs (n = 113)	1.30/0.77
	men	3861	4056	UGT1A1 SNP	1.17/0.86
				Non-UGT1A1 SNPs (n = 113)	1.43/0.70
	women	3252	3268	UGT1A1 SNP	1.18/0.84
				Non-UGT1A1 SNPs (n = 113)	1.48/0.67
Renal cell cancer	overall	10,784	20,406	UGT1A1 SNP	1.08/0.92
				Non-UGT1A1 SNPs (n = 111)	1.21/0.83
	men	3227	4916	UGT1A1 SNP	1.17/0.86
				Non-UGT1A1 SNPs (n = 109)	1.43/0.70
	women	1992	3095	UGT1A1 SNP	1.22/0.82
				Non-UGT1A1 SNPs (n = 109)	1.58/0.63
Lung cancer	overall	29,266	56,450	UGT1A1 SNP	1.05/0.95
				Non-UGT1A1 SNPs (n = 109)	1.12/0.89
	ever smokers	23,223	16,964	UGT1A1 SNP	1.07/0.93
				Non-UGT1A1 SNPs (n = 109)	1.17/0.85
	never smokers	2355	7504	UGT1A1 SNP	1.17/0.85
				Non-UGT1A1 SNPs (n = 109)	1.46/0.69
	adenocarcinoma	11,273	55,483	UGT1A1 SNP	1.07/0.93
				Non-UGT1A1 SNPs (n = 109)	1.18/0.85
	squamous cell	7426	55,627	UGT1A1 SNP	1.09/0.92
				Non-UGT1A1 SNPs (n = 109)	1.22/0.82
	small cell	2664	21,444	UGT1A1 SNP	1.15/0.87
				Non-UGT1A1 SNPs (n = 109)	1.39/0.72
Ovarian cancer	overall	25,509	40,941	UGT1A1 SNP	1.06/0.95
				Non-UGT1A1 SNPs (n = 111)	1.14/0.88
	serous	16,003	40,941	UGT1A1 SNP	1.07/0.94
				Non-UGT1A1 SNPs (n = 111)	1.16/0.86
Breast cancer	overall	122,977	105,974	UGT1A1 SNP	1.03/0.97
				Non-UGT1A1 SNPs (n = 112)	1.07/0.94
Endometrial cancer	overall	12,906	108,979	UGT1A1 SNP	1.07/0.94
				Non-UGT1A1 SNPs (n = 110)	1.16/0.86
Prostate cancer	overall	79,194	61,112	UGT1A1 SNP	1.04/0.96
				Non-UGT1A1 SNPs (n = 107)	1.09/0.92
Hodgkin’s lymphoma	overall	1200	6417	UGT1A1 SNP	1.24/0.81
				Non-UGT1A1 SNPs (n = 91)	1.65/0.61
Melanoma	overall	1804	1026	UGT1A1 SNP	1.31/0.77
				Non-UGT1A1 SNPs (n = 75)	1.86/0.54
Neuroblastoma	overall	1627	3254	UGT1A1 SNP	1.23/0.81
				Non-UGT1A1 SNPs (n = 57)	1.62/0.62

Abbreviations: N Number, OR odds ratio, SNP single nucleotide polymorphism