Table 3.

Medication-related osteonecrosis of the jaw (MRONJ) risk factors and predisposing conditions.

Local factors-related	Anatomic factors
	Poor oral hygiene
	Previous MRONJ
	Previous radiotherapy in the head and neck region
Demographic and systemic factors and other medication factors	Age
	Tobacco
	Anemia
	Diabetes
	Antiresorptive for osteoporosis < 3 years
	Antiresorptive for osteoporosis > 3 years
	Antiangiogenics + antiresorptives
	Corticosteroid therapy
	Rheumatoid arthritis
	Kind of tumor
Genetic factors	Single nucleotide polymorphisms (SNPs) in gene responsible for bone turnover