Table 1.
Details of telomeres measurements.
| Method | Sample Size | Reference |
|---|---|---|
| Terminal restriction fragment using Southern analysis | 51 subjects (23 males and 28 females, 37 White Americans, 14 African Americans) between ages of 1 month and 80 years. | [43] |
| Terminal restriction fragment using Southern analysis | 11 patients with CAD and 22 patients without CAD | [44] |
| Terminal restriction fragment using Southern analysis | 13 patients | [45] |
| Terminal restriction fragment using Southern analysis | 203 cases with a premature MI (50 years) and 180 controls | [51] |
| Modified monochrome multiplex quantitative PCR method | 105,055 individuals from Copenhagen (17,235 were diagnosed with ischemic heart disease between 1977 and 2013) Coronary ARtery DIsease Genome wide Replication and Meta-analysis (CARDIoGRAM) consortium dataset (184,967 participants, 60,837 cases of ischemic heart disease) |
[52] |
| Modified monochrome multiplex quantitative polymerase chain reaction method | 19,838 Danish general population participants | [53] |
| qPCR | 1511 CAD patients; 1553 control |
[56] |
| quantitative PCR-based method | 199 patients from 18 to 48 years old with first diagnosis of acute myocardial infarction; 190 control |
[58] |
| Southern blot analysis | 850 Framingham Heart Study participants (mean age 58 years, 58% women) | [59] |
| quantitative polymerase chain reaction | 334 randomly selected Flemish participants (mean age 1⁄4 46.5 years; 52.5% women) | [60] |
| quantitative polymerase chain reaction (qPCR)-based assay | 2211 healthy individuals and 2140 CHD patients | [61] |
| Southern blots | 154 French men and women (aged 31–76 years at baseline) | [62] |
| Q-FISH | 63 samples | [64] |
| Southern blots | 756 intact twins pairs | [65] |
| quantitative PCR | 9191 participants aged 20–84 | [67] |
| Southern blots of the terminal restriction fragments (TRFs) | 1156 adult (44% women) | [71] |
| Terminal restriction fragment using Southern analysis | 87 adults (aged 19–77 years) | [76] |
| FISH | 835 healthy individuals and 60 individuals with reduced telomerase activity | [77] |
| qPCR | 163 patients who underwent cardiac surgery | [78] |
| quantitative fluorescence in situ hybridization | 58 patients with myelodysplastic syndrome |
[79] |