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IDO-1, IDO-2, PD-L1, PD-L2 and INFγ interactions within the tumor microenviroment. IDO signaling pathways exert immune suppressive function by the activation of T-reg cell and the anergy of T effector cell. PD-L1/PD-1 inhibits T effector cell proliferation and stimulates T-reg cell proliferation while INFγ upregolates PD-L1, PD-L2 and IDO expression. Immune suppressive microenviroment promotes tumor growth increasing risk of progression (poor RFS) and unfavorable prognosis (worse OS).
