Table 4.

Univariate and multivariate analyses for overall survival (OS) (Cox’s proportional hazard regression model).

			OS
			Univariate Analysis			Multivariate Analysis
Variables		N. Pts at risk	HR	95% CI	* p	HR	95% CI	* p
Age
	<60	34
	≥60	157	1.04	0.60–178	0.88
Sex
	F (Ref)	54
	M	137	1.62	1.00–1.64	0.04	1.53	0.94	0.08
Smoking
	Never (Ref)	16	1
	Current	76	1.81	0.77–4.28	0.17
	Former	99	1.62	0.69–3.78	0.26
Histology
	Squamous (Ref)	69
	Adenocarcinoma	120	1.14	0.75–173	0.53
	Adenosquamous	2	0.93	0.12–6.85	0.94
p-Stage
	I (Ref)	101	1
	II	56	1.68	1.07–2.64	0.02	1.65	1.03–2.63	0.03
	III	34	1.55	0.90–2.66	0.10	1.46	0.83–2.57	0.18
PD-1
	Low < 4fc (Ref)	151
	High ≥ 4fc	40	1.26	0.78–2.04	0.29
PD-L1
	Low < 4fc (Ref)	77
	High ≥ 4fc	114	1.45	0.95–2.21	0.08
PD-L2
	Low < 4fc (Ref)	103
	High ≥ 4fc	88	1.37	0.91–2.04	0.12
IDO-1
	Low < 4fc (Ref)	110
	High ≥ 4fc	81	1.31	0.88–1.96	0.17
IDO-2
	Low < 4fc (Ref)	130
	High ≥ 4fc	61	1.47	0.97–2.22	0.06
INFγ
	Low < 4fc (Ref)	157
	High ≥ 4fc	34	1.33	0.80–2.20	0.26
PD-L1/IDO-2
	Low < 4fc (Ref)	141
	High ≥ 4fc	50	1.63	1.06–2.51	0.02	1.98	1.02–3.83	0.04
PD-L2/IDO-1
	Low < 4fc (Ref)	132
	High ≥ 4fc	59	1.54	1.02–2.33	0.04	1.92	1.10–3.35	0.02

Abbreviations: OS, Overall Survival; HR, Hazard Ratio; CI, Confidence Interval; PD-1, programmed cell death 1; PD-L1, programmed cell death 1 ligand 1; PD-L2, programmed cell death 1 ligand 2; IDO-1, indoleamine 2,3-dioxygenase 1; IDO-2, indoleamine 2,3-dioxygenase 2; IFNγ, Interferon-γ; * p value ≤ 0.05 in bold.