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In vitro cytotoxicity of BZ and CFZ on various melanoma cells.
| Test Melanoma Cells | IC50 (nM) * | |
|---|---|---|
| BZ | CFZ | |
| B16-F1 (murine) | 8.1 | 23.9 |
| B16-BL6 (murine, higher metastatic) | 10.1 | 43.4 |
| K-1735 (murine, carcinogen-induced) | 5.4 | 26.1 |
| DX3 (human) | 7.1 | 57.6 |
| A375P (human, low metastatic) | 10.4 | 28.2 |
| A375SM (human, highly metastatic) | 7.9 | 51.0 |
* IC50: the half maximal inhibitory concentration.
