Table 4.
Summary of Campylobacter jejuni vaccine antigens identified in this review.
| Vaccine Antigen | Role of Antigen in Promoting C. jejuni Colonization of Host | Reference |
|---|---|---|
| Bacterin | Killed-whole bacterial cells (multiple antigens) used for immunization | Okamura et al. [52] |
| C. jejuni glycoprotein Cj1496 | Invasion | Kakuda and DiRita [59] |
| Campylobacter adhesion protein to fibronectin (CadF) | Adhesion | Konkel et al. [60] |
| Campylobacter invasion antigen B (CiaB) | Invasion | Konkel [61] |
| Campylobacter surface-exposed lipoprotein A (JlpA) | Adhesion | Jin et al. [62] |
| Capsular polysaccharide (CPS) | Serum resistance | Keo et al. [63] |
| Component of multidrug efflux pump (CmeC) | Multidrug efflux system | Lin et al. [64] |
| Cysteine ABC transporter substrate-binding protein (CjaA) | Campylobacter solute-binding protein and a component of the ABC transport system | Muller et al. [65] |
| DNA binding protein for biofilm formation (Dps) | Biofilm formation | Theoret et al. [56] |
| Fibronectin-like protein A (FlpA) | Adhesion | Konkel et al. [66] |
| Flagellar hook-associated protein (FlgK) | Motility | Fernando et al., [67] and Neal-McKinney and Konkel [68] |
| Flagellar hook-basal body complex protein (FlgE-1) | Motility and deliver Campylobacter invasion antigens (Cia proteins) to host cells | Neal-McKinney and Konkel [68] |
| Flagellin | Motility | Nachamkin et al. [69] |
| Flagellin A protein (FlaA) | Motility, adherence, and invasion | Wassenaar et al. [70] |
| Flagellin protein family (FlgL) | Deliver Campylobacter invasion antigens (Cia proteins) to host cells | Neal-McKinney and Konkel [68] |
| Hemolysin co-regulated protein (Hcp) | Secretion tube and effector protein in Campylobacter jejuni Type VI secretion system (T6SS) for adhesion and invasion | Liaw et al. [71] and Lertpiriyapong et al. [72] |
| Hypothetical protein (YP_999817.1) | Not fully described | Meunier et al. [50] |
| Hypothetical protein (YP_999838.1) | Protein-protein interactions | Meunier et al. [50] |
| N-linked protein glycosylation (N-glycan) | Protect C. jejuni surface proteins from gut protease and attachment to host cells | Alemka et al. [73] and Karlyshev et al. [74] |
| Outer membrane proteins | Adhesion and invasion | Chart et al. [75] |
| Peptidoglycan-associated essential protein (PAL; Omp18; CjaD) | Maintenance cell wall | Godlewska et al. [76] |
| Whole-cell lysate | Adhesion and invasion | Konkel and Joens [77] |
| YP_001000437.1 | Activation/secretion of hemolysin | Meunier et al. [50] |