Table 1.
Baseline characteristics of all patients and clinical manifestation according to the GPS
| Total | GPS 0 | GPS 1 | GPS 2 | P‐value | |
|---|---|---|---|---|---|
| No. of patients | 56 | 31 | 16 | 9 | 0.732 |
| Age (years) | 71 | 71 | 72 | 71 | |
| Median range | 66–76 | 68–77 | 65–74 | ||
| Sex (%) | |||||
| Male | 40 (71.4) | 24 (77.4) | 12 (75.0) | 4 (44.4) | 0.145 |
| Female | 16 (28.6) | 7 (22.6) | 4 (25.0) | 5 (55.6) | |
| Performance status (%) | 0.303 | ||||
| 0, 1 | 49 (87.5) | 29 (93.5) | 13 (81.3) | 7 (77.8) | |
| 2–4 | 7 (12.5) | 2 (6.5) | 3 (18.8) | 2 (22.2) | |
| Smoking status (%) | 0.790 | ||||
| Never smoked | 3 (5.4) | 2 (6.5) | 0 (0.0) | 1 (11.1) | |
| Former smoker | 41 (73.2) | 23 (74.2) | 12 (75.0) | 6 (66.7) | |
| Current smoker | 12 (21.4) | 6 (19.4) | 4 (25.0) | 2 (22.2) | |
| Pack‐years | 50.0 | 50.0 | 49.5 | 53.0 | 0.702 |
| Median range | 36.7–82.5 | 38.1–58.7 | 15.0–60.2 | ||
| BMI (kg/m2) | 23.1 | 23.9 | 22.8 | 20.8 | 0.089 |
| Median range | 19.6–25.7 | 21.5–23.8 | 19.8–22.4 | ||
| Histology (%) | 0.305 | ||||
| Adenocarcinoma | 28 (50.0) | 17 (54.8) | 5 (31.3) | 6 (66.7) | |
| Squamous cell carcinoma | 25 (44.6) | 13 (41.9) | 9 (56.3) | 3 (33.3) | |
| Clinical stage (%) | 0.788 | ||||
| III | 10 (17.9) | 6 (19.4) | 2 (12.5) | 2 (22.2) | |
| IV or recurrence | 46 (82.1) | 25 (80.6) | 14 (87.5) | 7 (77.8) | |
| WBC (/μL) | 7100 | 6400 | 8400 | 7700 | 0.034 |
| Median range | 5500–7500 | 5825–9750 | 7350–9100 | ||
| Neutrophils (/μL) | 4436 | 4015 | 6085 | 5035 | 0.018 |
| Median range | 3478–4831 | 4065–7407 | 3033–6781 | ||
| Lymphocytes (/μL) | 1505 | 1650 | 1413 | 1243 | 0.122 |
| Median range | 1232–2056 | 970–1731 | 535–1974 | ||
| Eosinophils (/μL) | 137 | 159 | 129 | 100 | 0.845 |
| Median range | 83–258 | 51–251 | 37–242 | ||
| KL‐6 (U/mL) | 624 | 591 | 600 | 1034 | 0.301 |
| Median range | 462–843 | 433–961 | 564–1480 | ||
| %predicted FVC (%) | 103.1 | 104.6 | 98.5 | 84.3 | 0.612 |
| Median range | 95.0–111.0 | 79.8–126.5 | 55.8–121.3 | ||
| HRCT pattern (%) | 0.331 | ||||
| UIP pattern | 25 (44.6) | 12 (38.7) | 7 (43.7) | 6 (66.7) | |
| Non‐UIP pattern | 31 (55.4) | 19 (61.3) | 9 (56.2) | 3 (33.3) | |
| Emphysema (%) | 0.752 | ||||
| Yes | 45 (80.4) | 26 (83.9) | 12 (75.0) | 7 (77.8) | |
| No | 11 (19.6) | 5 (16.1) | 4 (25.0) | 2 (22.2) | |
BMI, body mass index; FVC, forced vital capacity; GPS, Glasgow Prognostic Score; HRCT, high‐resolution computed tomography; KL‐6, Krebs von den Lungen‐6; UIP, usual interstitial pneumonia; WBC, white blood cell.