Table 3.
Univariate and multivariate analyses of overall survival in patients with lung cancer and ILD
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| Variable | HR | 95% CI | P‐value | HR | 95% CI | P‐value |
| Age, per year increment | 1.00 | 0.96–1.04 | 0.858 | |||
| Sex (male vs. female) | 1.33 | 0.69–2.55 | 0.391 | |||
| Performance status (0, 1 vs. 2–4) | 2.73 | 1.16–6.37 | 0.020 | 1.82 | 0.75–4.39 | 0.183 |
| Smoking status (never vs. current or former) | 1.95 | 0.46–8.19 | 0.361 | |||
| Pack‐years, per pack year increment | 1.00 | 0.99–1.01 | 0.566 | |||
| BMI, per kg/m2 increment | 0.90 | 0.81–1.01 | 0.084 | |||
| Histology (adenocarcinoma vs. nonadenocarcinoma) | 0.87 | 0.47–1.63 | 0.677 | |||
| Clinical stage (III vs. IV or recurrence) | 1.73 | 0.72–4.15 | 0.213 | |||
| WBC, per/μL increment | 1.00 | 1.00–1.00 | 0.540 | |||
| Neutrophils, per/μL increment | 1.00 | 1.00–1.00 | 0.526 | |||
| Lymphocytes, per/μL increment | 1.00 | 0.99–1.00 | 0.988 | |||
| Eosinophils, per/μL increment | 1.00 | 0.99–1.00 | 0.881 | |||
| KL‐6, per U/mL increment | 1.00 | 0.99–1.00 | 0.564 | |||
| HRCT pattern (UIP pattern vs. non‐UIP pattern) | 0.97 | 0.52–1.80 | 0.920 | |||
| Emphysema (yes vs. no) | 1.02 | 0.49–2.12 | 0.938 | |||
| %predicted FVC, per % increment | 0.98 | 0.97–1.00 | 0.157 | |||
| GPS | ||||||
| 0 | 1 (Ref) | 1 (Ref) | ||||
| 1 | 2.59 | 1.17–5.72 | 0.018 | 2.34 | 1.04–5.26 | 0.039 |
| 2 | 5.27 | 2.04–13.58 | 0.001 | 4.61 | 1.74–12.2 | 0.002 |
BMI, body mass index; CI, confidence interval; FVC, forced vital capacity; GPS, Glasgow Prognostic Score; HR, hazard ratio; HRCT, high‐resolution computed tomography; ILD, interstitial lung disease; KL‐6, Krebs von den Lungen‐6; Ref, reference; UIP, usual interstitial pneumonia; WBC, white blood cells.