Table 6.
Results of secondary analysis of groups matched by diagnosis delay and follow-up time (N = 620)
| Variable | Multivariate Analysis |
||
|---|---|---|---|
| HR | 95% CI | P Value | |
| Noninvasive ventilation | 0.68 | 0.51–0.91 | 0.01 |
| Age at diagnosis per decade | 1.18 | 1.06–1.32 | 0.004 |
| Body mass index class | |||
| <18.5 kg/m2 | 1.90 | 1.17–3.10 | 0.01 |
| 18.5–24.9 kg/m2 | — | — | — |
| 25–29.9 kg/m2 | 0.76 | 0.56–1.03 | 0.07 |
| ≥30 kg/m2 | 0.57 | 0.38–0.86 | 0.007 |
| ALSFRS-R dyspnea score | |||
| >2 | — | — | — |
| ≤2 | 1.44 | 1.09–1.89 | 0.009 |
| Forced vital capacity | |||
| <40% | 2.58 | 1.77–3.75 | <0.001 |
| 40–49% | 2.00 | 1.40–2.86 | <0.001 |
| 50–59% | 1.60 | 1.10–2.32 | 0.01 |
| ≥60% | — | — | — |
| Time-varying covariate | |||
| Daily hours of noninvasive ventilation | 1.002 | 0.999–1.005 | 0.16 |
Definition of abbreviations: ALSFRS-R = Amyotrophic Lateral Sclerosis Functional Rating Scale Revised; CI = confidence interval; HR = hazard ratio.