Table 2.
Changes in clinical parameters.
| Variable | Baseline | Follow-up | Change (%) | p-value* |
|---|---|---|---|---|
| Hemodynamics | ||||
| Mean RAP, mmHg | 6.5 (4.0–8.0) | 4.0 (3.0–5.0) | −2.5 (−38) | 0.005 |
| Mean PAP, mmHg | 56.0 (46.3–65.5) | 40.0 (30.0–47.0) | −16.0 (−29) | <0.001 |
| PAWP, mmHg | 7.5 (6.0–9.8) | 9.0 (8.0–11.0) | 1.5 (20) | 0.68 |
| CO, L/min | 3.3 (2.4–4.5) | 6.0 (5.1–6.7) | 2.7 (82) | <0.001 |
| CI, L/min per m2 | 2.2 (1.7–2.7) | 3.8 (3.3–4.5) | 1.6 (73) | <0.001 |
| PVR, WU | 13.5 (8.8–21.5) | 4.7 (2.8–6.9) | −8.8 (−65) | <0.001 |
| Echocardiography | ||||
| TAPSE, cm | 1.5 (1.3–1.8) | 2.3 (1.9–2.6) | 0.8 (53) | 0.001 |
| RVS’, cm | 9.7 (7.8–11.8) | 13.3 (12.4–14.4) | 3.6 (37) | 0.001 |
| RAA, cm2 | 17.2 (14.9–21.3) | 16.4 (14.1–21.0) | −0.8 (−5) | 0.49 |
| RVEDA, cm2 | 26.9 (22.8–33.1) | 24.1 (21.0–30.3) | −2.8 (−10) | 0.21 |
| RVESA, cm2 | 20.4 (16.3–23.9) | 16.4 (13.8–21.1) | −4.0 (−20) | 0.006 |
| FAC, % | 23.6 (16.2–26.9) | 32.9 (29.1–35.8) | 9.3 (39) | <0.001 |
| WHO-FC | ||||
| I or II | 4 (22) | 16 (89) | – | – |
| III or IV | 14 (78) | 2 (11) | – | – |
| 6MWD, m | 405.0 (303.0–441.8) | 472.0 (439.5–493.5) | 67.0 (17) | 0.046 |
| BNP, pg/mL | 187.8 (36.7–379.5) | 17.5 (10.3–27.2) | −170.3 (−91) | <0.001 |
Data are expressed as number (%) or median (interquartile range). The number of subjects at baseline and follow-up was the same equal number in each parameter. Eighteen patients were analyzed in hemodynamics, and 20 patients in echocardiography.
p-value was calculated using a Wilcoxon’s signed rank test for comparison of baseline and follow-up.
6MWD, 6-minute walk distance; BNP, B-type natriuretic peptide; CI, cardiac index; CO, cardiac output; FAC, fractional area change; PAP, pulmonary arterial pressure; PAWP, pulmonary arterial wedge pressure; PVR, pulmonary vascular resistance; RAA, right atrial area; RAP, mean right atrial pressure; RVEDA, right ventricular end-diastolic area; RVESA, right ventricular end-systolic area; RVS’, right ventricular systolic excursion velocity; TAPSE, tricuspid annular plane systolic excursion; WHO-FC, World Health Organization functional class; WU, Wood units.