Table 3.
Changes in clinical parameters among treatment-naïve patients at baseline.
| Variable | Baseline | Follow-up | Change (%) | p-value* |
|---|---|---|---|---|
| Hemodynamics | ||||
| Mean RAP, mmHg | 7.5 (4.3–8.8) | 4.0 (3.3–5.0) | −3.5 (−47) | 0.022 |
| Mean PAP, mmHg | 63.0 (55.0–75.8) | 44.5 (37.0–51.5) | −18.5 (−29) | 0.006 |
| PAWP, mmHg | 7.5 (6.3–9.8) | 8.0 (6.5–10.3) | 0.5 (7) | 0.61 |
| CO, L/min | 3.1 (2.4–4.3) | 5.9 (5.1–7.2) | 2.8 (90) | 0.006 |
| CI, L/min per m2 | 2.1 (1.7–2.5) | 4.2 (3.5–4.6) | 2.1 (100) | 0.006 |
| PVR, WU | 17.5 (13.2–21.9) | 5.9 (3.8–9.6) | −11.6 (−66) | 0.006 |
| Echocardiography | ||||
| TAPSE, cm | 1.4 (1.3–1.5) | 2.3 (2.1–2.7) | 0.9 (64) | 0.009 |
| RVS’, cm | 9.3 (7.9–10.8) | 13.5 (13.0–14.3) | 4.2 (45) | 0.035 |
| RAA, cm2 | 18.5 (15.0–21.1) | 15.2 (13.5–16.7) | −3.3 (−18) | 0.076 |
| RVEDA, cm2 | 27.0 (25.0–33.2) | 23.6 (21.0–24.6) | −3.4 (−13) | 0.058 |
| RVESA, cm2 | 22.9 (18.7–25.4) | 14.8 (14.0–16.8) | −8.1 (−35) | 0.009 |
| FAC, % | 22.9 (15.9–25.2) | 33.1 (29.5–35.0) | 10.2 (45) | 0.018 |
| WHO-FC | ||||
| I or II | 1 (10) | 8 (80) | ||
| III or IV | 9 (90) | 2 (20) | ||
| 6MWD, m | 400.0 (326.5–432.0) | 471.5 (451.5–479.2) | 71.5 (18) | 0.030 |
| BNP, pg/mL | 200.8 (41.9–379.5) | 20.2 (12.6–24.5) | −180.6 (−90) | 0.006 |
Data are expressed as number (%) or median (interquartile range). The number of subjects at baseline and follow-up was the same equal number in each parameter. Ten patients were analyzed in hemodynamics, and nine patients in echocardiography.
p-value was calculated using a Wilcoxon’s signed rank test for comparison of baseline and follow-up.
6MWD, 6-minute walk distance; BNP, B-type natriuretic peptide; CI, cardiac index; CO, cardiac output; FAC, fractional area change; PAP, mean pulmonary arterial pressure; PAWP, pulmonary arterial wedge pressure; PVR, pulmonary vascular resistance; RAA, right atrial area; RAP, mean right atrial pressure; RVEDA, right ventricular end-diastolic area; RVESA, right ventricular end-systolic area; RVS’, right ventricular systolic excursion velocity; TAPSE, tricuspid annular plane systolic excursion; WHO-FC, World Health Organization functional class; WU, Wood units.