Figure 2.

SENP3 was involved in high glucose-induced endothelial cell dysfunction: (a) the efficacy of SENP3 knockdown by siRNA was verified by western blotting, (b) high glucose-induced HAEC death was reversed by SENP3 knockdown, (c) high glucose-induced HAEC apoptosis was reversed by SENP3 knockdown, and (d) high glucose-induced HAEC migration suppression was reversed by SENP3 knockdown. All the experiments were repeated at least thrice.

^*p < 0.05 versus normal glucose, ^#p < 0.05 versus high glucose + control siRNA.