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ROS related signaling is involved in the effects of SENP3 on HAECs in the setting of high glucose: (a) ROS dependent SENP3 expression in the setting of high glucose, (b) efficacy of Nox4 knockdown by siRNA, (c) decreased SENP3 level could be also achieved by Nox4 siRNA, and (d) intracellular ROS level measurement.
*p < 0.05 versus normal glucose, #p < 0.05 versus high glucose.
