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. 2021 Feb 15;12(2):277. doi: 10.3390/genes12020277

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Fold change transactivation by wild-type P53 family proteins. Yeast cells expressing different P53 family isoforms by an inducible GAL1,10 promoter were grown for 8 h in Galactose 1% to evaluate their transactivation ability. (A) Evaluation of wild-type P53, P63, and P73 (ΔN variants: ΔN40P53α, ΔNP63α, and ΔNP73α; TA variants: full-length P53, TAP63α, and TAP73α) transcriptional activity as fold change over the empty vector in presence of the P53 response element (RE) from the PUMA target gene (yLFM-PUMA) or a G4 prone sequence (yLFM-KSHV). (B) Evaluation of transcriptional activity as in panel A in the presence of the G4 prone sequence upstream (yLFM-KSHV-PUMA) or downstream (yLFM-PUMA-KSHV) of the P53 RE from the PUMA target gene.