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. 2021 Mar 1;21:207. doi: 10.1186/s12885-021-07857-x

Table 2.

Top 50 DEG, 29 upregulated and 21 downregulated, observed exclusively in all the ten samples of adenocarcinoma (presented by FC)

Gene RefSeq Description FCa FDRb
Upregulated
SIM2 NM_005069.3 single-minded family bHLH transcription factor 2 4.26 7.63E-07
FAP NM_001291807.1 fibroblast activation protein, alpha 3.34 0.00112
FUT1 NM_000148.3 fucosyltransferase 1 3.04 0.00017
ESM1 NM_001135604.1 endothelial cell-specific molecule 1 2.98 0.00060
FABP6 NM_001040442.1 fatty acid binding protein 6, ileal 2.95 0.00420
COL1A1 NM_000088.3 collagen, type I, alpha 1 2.75 0.00181
WNT2 NM_003391.2 wingless-type MMTV integration site family member 2 2.65 0.00601
ELN NM_000501.3 elastin 2.22 0.00072
ETV4 NM_001079675.2 ets variant 4 2.18 0.00060
ACAN NM_001135.3 aggrecan 2.12 0.00107
LARP6 NM_001286679.1 La ribonucleoprotein domain family, member 6 2.00 0.00111
FADS1 NM_013402.4 fatty acid desaturase 2.00 0.00099
SCRN1 NM_001145513.1 secernin 1 1.97 0.00188
LY6E NM_001127213.1 lymphocyte antigen 6 complex, locus E 1.95 0.00691
TCFL5 NM_006602.2 transcription factor-like 5 (basic helix-loop-helix) 1.91 0.00426
PROCR NM_006404.4 protein C receptor, endothelial 1.90 0.00745
FAM150A NM_001195732.1 family with sequence similarity 150 member A 1.87 0.00283
COL5A2 NM_000393.3 collagen, type V, alpha 2 1.73 0.00601
FAM72D NM_207418.2 family with sequence similarity 72 member D 1.62 0.00262
SPARC NM_003118.3 secreted protein, acidic, cysteine-rich (osteonectin) 1.62 0.00420
PARVB NM_001003828.2 parvin, beta 1.56 0.01610
VEGFA NM_001025366.2 vascular endothelial growth factor A 1.46 0.00123
UBE2C NM_001281741.1 ubiquitin-conjugating enzyme 1.45 0.00060
AUNIP NM_001287490.1 aurora kinase A and ninein interacting protein 1.35 0.00177
GK NM_000167.5 glycerol kinase 1.26 0.00437
LRP8 NM_001018054.2 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 1.15 0.01137
DIAPH3 NM_001042517.1 diaphanous-related formin 3 1.11 0.00178
FAM162B NM_001085480.2 family with sequence similarity 162 member B 1.05 0.04851
CENPJ NM_018451.4 centromere protein J 1.04 0.00243
Downregulated
CLCA1 NM_001285.3 chloride channel accessory 1 −7.97 0.00155
HEPACAM2 NM_001039372.2 HEPACAM family member 2 −4.05 0.00131
B3GNT6 NM_138706.4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 −4.03 0.00177
BEST2 NM_017682.2 bestrophin 2 −3.86 0.00099
L1TD1 NM_001164835.1 LINE-1 type transposase domain containing 1 −3.52 0.02738
ADH1A NM_000667.3 alcohol dehydrogenase 1A (class I) alpha polypeptide −3.48 0.00852
ADH1C NM_000669.4 alcohol dehydrogenase 1C (class I), gamma polypeptide −3.39 0.00776
GALNT8 NM_017417.1 polypeptide N-acetylgalactosaminyltransferase 8 −3.24 0.00084
SPTLC3 NM_018327.2 serine palmitoyltransferase, long chain base subunit 3 −2.99 0.00244
SPINK2 NM_001271718.1 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) −2.49 0.01166
ATOH8 NM_153778.3 atonal homolog 8 −2.32 0.00643
KCNMA1 NM_001014797.2 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 −2.27 0.00060
NEURL NM_004210.4 neuralized E3 ubiquitin protein ligase 1 −2.19 0.00109
PIGR NM_002644.3 polymeric immunoglobulin receptor −2.14 0.01272
MFSD4 NM_181644.4 major facilitator superfamily domain containing 4 −2.11 0.00201
ARHGAP44 NM_014859.4 Rho GTPase activating protein 44 −2.06 0.00060
SERTAD4 NM_019605.3 SERTA domain containing 4 −1.82 0.00072
PLA2G10 NM_003561.1 phospholipase A2, group X −1.73 0.04438
NEDD4L NM_001144964.1 eural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase −1.61 0.00123
ACADVL NM_000018.3 acyl-CoA dehydrogenase, very long chain −1.20 0.00099
PID1 NM_001100818.1 phosphotyrosine interaction domain containing 1 −1.19 0.01212

aFC (log2 fold change); bFDR (false discovery rate). The genes in bold are the same ones selected in Table 1 for validation by RT-qPCR