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Apigenin (API) activated the AMP-activated protein kinase (AMPK) pathway both in vitro and in vivo. (A) Protein expression of AMPK and GSK-3β in mice liver. (B) Protein expression of AMPK and GSK-3β in L-02 cells. (C) Theoretical binding mode of API at the binding site of AMPK. Data are expressed as means ± SEM (n = 6 in mice and n = 3 in L-02 cells).
