Table 1.
The genetic features of B-cell lymphoma
| Type | Recurrent translocations (if known) | Recurrently mutated genes (if known) |
|---|---|---|
| Pre-germinal center origin | ||
| B-cell prolymphocytic leukemia (B-PLL) | t(8;14)(MYC/IGH), t(2;8)(IGK/MYC), t(8;22)(MYC/IGL) |
MYC, TP53 |
| Mantle cell lymphoma | t(11;14)(CCND1/IGH), t(2;11)(IGK/CCND1), t(11;22)(CCND1/IGL), t(8;14)(MYC/IGH), t(3;14)(BCL6/IGH) |
ATM, CCND1, KMT2D, NOTCH1/2, TP53 |
| Germinal center origin | ||
| Burkitt lymphoma | t(8;14)(MYC/IGH), t(2;8)(IGK/MYC), t(8;22)(MYC/IGL) |
MYC, ID3, DDX3X, TP53, TCF3, CCND3, RHOA, SMARCA4, ARID1A |
| Diffuse large B-cell lymphoma (DLBCL), NOS | BCL2, BCL6, and MYC rearrangements | EZH2, SGK1, GNA13, MYD88, ETV6, CD78B |
| Follicular lymphoma | t(14;18)(IGH/BCL2) | BCL2, KMT2D, EZH2, BCL6, CREBBP, EP300, FAS, MEF2B |
| Follicular lymphoma (pediatric type) | None | TNFRSF14, MAP2K1 |
| High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements | MYC, BCL2, and/or BCL6 rearrangements | TP53, MYD88, ID3 |
| Primary diffuse large B-cell lymphoma of the CNS | IG genes, BCL6 and MYC rearrangements | MYD88, CD79B, INPP5D, CBL, BLNK, CARD11, MALT1, BCL2 |
| Post-germinal center origin | ||
| ALK-positive large B-cell lymphoma | t(2;17)(ALK/CLTC), t(2;5)(ALK/NPM), ALK rearrangements with SQSTM1, SEC31A |
|
| Chronic lymphocytic leukemia (CLL)/Small lymphocytic lymphoma (SLL) | t(14;18)(IGH/BCL2), t(14;19)(IGH/BCL3) |
NOTCH1, SF3B1, TP53, ATM, BIRC3, POT1, MYD88 |
| Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) | t(11;18)(BIRC3/MALT1), t(14;18)(IGH/MALT1), t(1;14)(BCL10/IGH), t(3;14)(FOXP1/IGH) |
MYD88 |
| Hairy cell leukemia | None | BRAF, MAP2K1 |
| Hairy cell leukemia variant | TP53, MAP2K1 | |
| Lymphoplasmacytic lymphoma (LPL)/Waldenstrom's macroglobulinemia (WM) | None | MYD88, CXCR4, ARID1A, TP53, CD79B, KMT2D, MYBBP1A |
| Nodal marginal zone lymphoma | None | |
| Plasmablastic lymphoma | MYC rearrangements with IG genes | |
| Primary effusion lymphoma | None | BCL6 |
| Splenic marginal zone lymphoma | t(14;18)(IGH/BCL2), t(11;14)(CCND1/IGH), t(11;18)(BIRC3/MALT1), t(14;18)(IGH/MALT1), t(1;14)(BCL10/IGH), t(2;7)(IGK/CDK6) |
NOTCH2, KLF2 |
| Cutaneous lymphomas | ||
| Primary cutaneous diffuse large B-cell lymphoma, leg-type | t(3;14)(BCL6/IGH), t(8;14)(MYC/IGH) |
MYD88, CARD11, CD78B, TNFAIP3 |
| Primary cutaneous follicle center lymphoma | t(14;18)(IGH/BCL2) | CDKN2A, CDKN2B |
| Unknown origin | ||
| High-grade B-cell lymphoma, NOS | None | |
| Intravascular large B-cell lymphoma | ||
| Large B-cell lymphoma with IRF4 rearrangement | t(6;14)(IRF4/IGH), t(3;14)(BCL6/IGH) |
TP53 |
| Primary mediastinal (thymic) large B-cell lymphoma | MHC CIIA rearrangements with PDL1/2, PDL1/2 rearrangements | SOCS1, STAT6, PTPN1, BCL6, ITPKB, MFHAS1, XPO1 |
| Splenic diffuse red pulp small B-cell lymphoma | t(9;14)(PAX5/IGH) | TP53, CCND3, NOTCH1, MAP2K1, BRAF, SF3B1 |
| T-cell/histiocyte-rich large B-cell lymphoma | ||
Major B-cell lymphoma subtypes grouped by cell of origin with characteristic translocations and recurrently mutated genes.
NOS, Not otherwise specified; CNS, central nervous system; ALK, anaplastic lymphoma kinase.