Figure 9.

Mutagenicity versus carcinogenicity. (Left) An oft-cited early report showing a strong correlation (R = ∼0.9). (Right) A more thorough study showing a much weaker correlation (R = ∼0.3). (AFB) aflatoxin B₁, (HAA) N-hydroxy-2-acetylaminofluorene, (SAC) saccharin. (Left, Reprinted from Meselson M, Russell K. 1977. In Origins of Human Cancer (ed. Hiatt H, et al.), pp. 1473–1481, © Cold Spring Harbor Laboratory Press; right, reprinted, with permission, from McCann, et al. 1988. Mutat Res 205: 183–195, © Elsevier.)