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. 2021 Mar 1;35(5-6):329–334. doi: 10.1101/gad.346460.120

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© 2021 Sinturel et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genes & Development, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 1. — Long-term recording of circadian whole-body bioluminescence. (A–C) Whole-body recording of a hairless Per2::luc mouse entrained by a skeleton photoperiod. Luciferin was delivered as indicated. (A) Bioluminescence. (B) Spontaneous locomotor activity. (C) Drinking activity. (Orange, gray, and light blue lines in A–C) Raw data (1-min photon counts, 1-min activity counts, and 1-min water consumption, respectively), (darker lines in A–C) 120-min time-binned traces. (D,E) Whole-body Per2::luciferase and hepatic Rev-erbα-luciferase recordings from two different animals kept in constant darkness and receiving luciferin through Alzet pumps (D) or with the drinking water (E). (Light lines) Raw data, (darker lines) 120-min time-binned traces. (F,G) Relationship between the phases (F) and the period lengths (G) of Per2::luciferase and hepatic Rev-erbα-luciferase expression of mice receiving luciferin in the drinking water (n = 5) or by an Alzet micro-osmotic pumps (n = 7). Mice were kept in constant darkness.