Figure 4.

Histone 3 N-terminal acetylation mutants increase replication fork velocity. (A) Replicon length increases in mutants deficient of histone H3 N-terminal acetylation: Shown are the replicon lengths of the indicated mutants. (B) H3 N-terminal mutations increase fork velocity: Shown are the fork velocity and initiation frequency of the indicated mutants, as defined from DNA content of cells progressing synchronously through S phase (for details, see Supplemental Fig. S3). (C–F) H3 N-terminal mutations accelerate Pol2 progression: same as Figure 2, F through H, for the indicated mutants.