Table 1.
Histone modifying enzymes relevant to gynaecological cancers.
| Enzyme | Enzyme Type | Mechanism | Modification | Cancer | Expression | Reference(s) |
|---|---|---|---|---|---|---|
| EZH2 | Writer | Methyltransferase | H3K27me2, H3K27me3 | Ovarian, Endometrial |
↑ | [14,15] |
| KDM6B | Eraser | Demethylase | H3K27me2, H3K27me3 | Ovarian | ↑ | [16] |
| EHMT2 | Writer | Methyltransferase | H3K9me, H3K9me2 | Ovarian, Endometrial |
↑ | [15,17] |
| LSD1 | Eraser | Demethylase | H3K4me2, H3K4me | Ovarian, Endometrial |
↑ | [18] |
| LSD1 | Eraser | Demethylase | H3K9me | Endometrial | ↑ | [19] |
| EP400 | Writer | Acetyltransferase | HAc | Cervical | ↓ | [20] |
| KDM5C | Eraser | Demethylase | H3K4me, H3K4me2, H3K4me3 | Cervical | ↓ | [20] |
| SMYD2 | Writer | Methyltransferase | H3K4me3 | Ovarian | ↑ | [21] |
| SMYD3 | Writer | Methyltransferase | H3K4me3, H4K5me | Cervical | ↑ | [21] |
| DOT1L | Writer | Methyltransferase | H3K79me2 | Ovarian | ↑ | [22] |
| RNF20-RNF40 complex | Writer | Ubiquitinating enzyme | H2Bub | Ovarian | ↓ | [23,24] |
| KDM4A | Eraser | Demethylase | H3K9me3, H3K36 | Ovarian | ↑ | [25] |
| KDM3A | Eraser | Demethylase | H3K9me, H3K9me2 | Ovarian | ↑ | [26] |
| SUV39H2 | Writer | Methyltransferase | H3K9me3 | Cervical | ↑ | [27] |
| KDM4B | Eraser | Demethylase | H3K9me2, H3K9me3 | Endometrial | ↑ | [28] |
| HDAC1 | Eraser | Deacetylase | HAc | Ovarian, Endometrial |
↑ | [29,30] |
| HDAC2 | Eraser | Deacetylase | HAc | Ovarian, Endometrial |
↑ | [29,30] |
| HDAC3 | Eraser | Deacetylase | HAc | Ovarian, Endometrial |
↑ | [29,30] |
| HDAC7 | Eraser | Deacetylase | HAc | Ovarian | ↑ | [31] |
| HDAC12 | Eraser | Deacetylase | HAc | Ovarian | ↑ | [31] |
| BRD4 | Reader | BET protein | - | Ovarian | ↑ | [32] |
Up arrows (↑) represent increased expression in indicated cancer relative to normal tissue, down arrows (↓) represent decreased expression in indicated cancer relative to normal tissue.