TABLE 1.
Summary of Viloxazine and d-Amphetamine Plasma Pharmacokinetic Parameters
| Viloxazine Plasma PK | d-Amphetamine Plasma PK | ||||
|---|---|---|---|---|---|
| Parameter | Viloxazine Extended-Release Alone (n = 34) | Combination (n = 34) | Parameter | Lisdexamfetamine Alone (n = 35) | Combination (n = 34) |
| Cmax, μg/mL | 4.98 ± 1.12 (22.58) | 4.76 ± 0.85 (17.76) | Cmax, ng/mL | 54.8 ± 7.84 (14.30) | 62.0 ± 10.3 (16.57) |
| AUC0-t, h*μg/mL | 103.5 ± 27.68 (26.75) | 103.7 ± 27.67 (26.69) | AUC0-t, h*ng/mL | 864.5 ± 156.6 (18.11) | 948.7 ± 168.1 (17.72) |
| AUCinf, h*μg/mL | 104.6 ± 27.79 (26.57) | 105.7 ± 27.31 (25.84) | AUCinf, h*ng/mL | 876.2 ± 156.8 (17.89) | 960.2 ± 169.3 (17.64) |
| Tmax, h | Median (range) | Tmax, h | Median (range) | ||
| 5.00 (3.00–10.00) | 5.00 (3.00–10.12) | 3.00 (2.00–5.03) | 3.54 (2.00–8.02) | ||
| t1/2, h | 7.01 ± 2.67 (38.17) | 6.28 ± 2.62 (41.76) | t1/2, h | 11.43 ± 1.94 (16.99) | 11.42 ± 1.96 (17.14) |
All data reported as mean ± SD (CV%) unless otherwise specified.