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. 2021 Mar 1;131(5):e143645. doi: 10.1172/JCI143645

Figure 2. TXNDC5 was highly upregulated in renal fibroblasts, but not in TECs, endothelial cells, or podocytes, of the fibrotic kidneys.

Figure 2

(A and C) IF staining of TXNDC5 (red) on sections of fibrotic kidneys induced by UUO in Col1a1-GFPTg mice showed TXNDC5 was mainly expressed in collagen-secreting renal fibroblasts (green), both in renal cortex and medulla (n = 6). Cell nuclei were stained with DAPI (blue). Scale bar: 100 μm. (B) IF staining of TXNDC5 (green) on section of fibrotic kidneys induced by UUO in Cdh16-Cre, NPHS2-Cre, and Tie2-Cre/ERT2 tdTomato mice. Cell nuclei were stained with DAPI (blue). Scale bar: 100 μm. (D) A pie chart to illustrate the proportion of TXNDC5+ cells in different types of kidney cells in the UUO-induced fibrotic kidneys. Data are representative of 3 or more independent experimental replicates. Data in C are presented as mean ± SEM.