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. 2021 Mar 1;131(5):e141380. doi: 10.1172/JCI141380

Figure 2. Histologic analysis of mouse kidney tissue demonstrates podocyte filter barrier rescue by GDC-0879.

Figure 2

(A) Electron micrographs of kidneys of control, vehicle-treated KDKD, and GDC-0879–treated KDKD mice to assess integrity of the kidney filter, measured by the appearance and number of podocyte foot processes (arrowheads). Diffuse foot process simplification (called effacement) is seen in glomeruli of vehicle-treated KDKD mice. Rescue of foot process effacement is observed following treatment with GDC-0879. Pod, podocyte; Mes, mesangial cell; CL, capillary lumen; FP, podocyte foot processes. Scale bars: 2 μm (upper); 1 μm (lower). (B) Vehicle-treated KDKD mice have significantly reduced podocyte foot process numbers, which is reversed following treatment with GDC-0879. n = 5 animals per condition; 14–16 images quantified per animal.Shapiro-Wilk normality test, 1-way ANOVA, Tukey’s multiple comparison test. (C) Decreased number of foot processes correlates with escalating individual animal proteinuria levels. **P < 0.01; ****P < 0.0001.