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. 2021 Mar 1;131(5):e141380. doi: 10.1172/JCI141380

Figure 6. Mapk and lipid peroxidation gene-expression profiles in human kidney diseases associated with podocyte injury.

Figure 6

(A) Summary of NephroSeq, version 5, data filtered for significant results (P < 0.05), fold change > 1.5 (disease versus control), and Pearson’s correlation coefficient, r > 0.5 (Proteinuria) show increased GPX4 and Mapk pathway gene expression in human kidney disease samples (left) and correlation with disease severity, as measured by proteinuria (right). SYNPO expression, used as a control, is expected to be decreased in diseases involving podocyte injury. (B) Scatter plot showing correlation between Mapk pathway gene expression, RAF1, and proteinuria in human FSGS. (C) Scatter plot showing correlation among lipid peroxidation gene expression, GPX4, and proteinuria in human kidney disease samples (FSGS). (D) Scatter plot showing correlation between GPX4 and RAF1 gene expression in human FSGS.