Skip to main content
. 2021 Mar 1;131(5):e140853. doi: 10.1172/JCI140853

Figure 8. Doxycycline administration significantly ameliorates filarial lymphatic pathology.

Figure 8

(A) Schematic of doxycycline intervention in BmL3-infected C57BL/6J mice. (B) Representative images, (C) aberrant lymphatics, (D) hind-limb ICG dye retention in sham, BmL3+vehicle, or BmL3+doxycycline–treated mice, 14 dpi (n = 13 sham, n = 23 BmL3+vehicle, n = 20 BmL3+doxycycline). Data plotted as percentage change normalized to mean values of the BmL3+vehicle control group in order to compare data pooled from independent experiments. (E) Evan’s blue dermal retention from left-hind-limb skin (n = 18 sham; n = 21 BmL3+vehicle; n = 11 BmL3+doxycycline). Data were pooled from 3 individual experiments. Histograms show the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 by 1-way ANOVA with Tukey’s multiple-comparison post hoc test.