MMP-3 and MMP-13 are elevated in HIV-infected human brain tissue. MMP-3 and MMP-13 were detected by Western blot in post-mortem human cortical lysates. Representative bands from infected and non-infected are shown. A. MMP-3 (53 kDa) levels were elevated in HIV-infected tissue (unpaired t test, df = 34, t = 4.534, p < 0.0001, n = 36). B. Catalytic MMP-13 (26 kDa) levels were also elevated in HIV-infected tissue (unpaired t test, df = 37, t = 2.902, p = 0.0062, n = 38). ** p < 0.01, **** p <0.0001