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. 2021 Feb 16;11(2):509. doi: 10.3390/ani11020509

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Digital colored transmission electron microscopy micrographs of the control group (A) and aflatoxin B1-treated group III (B,C). (A) Blood sinusoid (S) lined with fenestrated endothelium (double arrows). The lumen of the sinusoid contains Kupffer cells (red). The blood sinusoid is surrounded by telocytes (TCs; yellow), Ito cells (IT) containing fat droplets, and pit cells (arrowhead). Note the TCs’ cell body (biforked arrow), telopodes (arrow), and bundles of collagen fibers (*). (B) Blood sinusoid in the aflatoxin B1-treated group exhibiting a large gap in the endothelial lining (double arrows). It is surrounded by enlarged pit cells (arrowhead) and Ito cells (IT) which are overloaded with large fat droplets. (C) Kupffer cells (red) are located within the sinusoid and attached to the endothelial cell (E) through its cytoplasmic extensions (arrowheads). They contain lysosomes (arrow) and vacuoles (V).