Table 2.
Genomic alterations and markers for Small cell lung carcinoma (SCLC).
| Marker | Genetic Alteration | Comments |
|---|---|---|
| RB1 | Loss | 95% of SCLC |
| TP53 | Mutation | 65% of SCLC |
| Chromosome arm 3p | Deletion | 91% of SCLC |
| MYC | Mutation | Variable |
| BCL2 | Mutation | Variable |
| PTEN | Mutation | Variable |
| SLIT2 | Mutation | Variable |
| CREBBP | Mutation | Variable |
| EPHA7 | Mutation | Variable |
| FGFR1 | Mutation | Variable |
| c-KIT | Increased Expression | Described in some SCLC subsets |
| MYC, MYCL1, MYCN | Amplification | Described in some SCLC subsets |
| PTEN | Loss | Described in some SCLC subsets |