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. 2021 Feb 16;22(4):1934. doi: 10.3390/ijms22041934

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The utilization of I53-50 cage in vaccine design. (a) Design of I53-50 cage composed with 120 subunits of two component proteins. Modified from [71]. Reprinted with permission from American Association for the Advancement of Science (AAAS). (b) The utilization of I53-50 as a carrier for respiratory syncytial virus antigen (DS-Cav1) conjugation; and (c) HIV-1 antigen (BG505 SOSIP) conjugation with negative stain electron microscopy (EM) images on the right side, respectively. Reproduced with modification from [72] and [73].