Table 1.
Bacteriophage T4 building blocks as carriers for vaccines against infectious diseases.
| Carriers | Target Disease(s) | Antigen(s) | References |
|---|---|---|---|
| fibritin | HIV-1 | Uncleaved, soluble gp140 glycoproteins | [89] |
| fibritin | HIV-1 | a noncleavable gp140 envelope protein | [90] |
| foldon | HIV-1 | gp140 | [91,92,93] |
| foldon | influenza | HA | [94,95] |
| foldon | influenza | HA stem domain | [96] |
| foldon | influenza | HA1 | [97,98] |
| foldon | RSV | RSV fusion (F) glycoprotein | [99,100] |
| foldon | MERS-CoV | Receptor-binding domain (RBD) | [101] |
| foldon | MERS-CoV | MERS-CoV-S1, SARS-CoV-2-S1 | [102] |
| soc | Foot-and-mouth disease (FMD) | P1, proteinase 3C | [103] |
| soc | Anthrax, plague | Anthrax PA, plague F1mutV | [104] |
Abbreviations: HA, haemagglutinin; RSV, respiratory syncytial virus; MERS-CoV, middle east respiratory syndrome coronavirus; PA, protective antigen.