Table 1.
Adipocyte- and fibroblast-based therapeutic targets to improve wound healing.
| Inflammatory Defect during Wound Healing | Mesenchymal Cell-Based Approach to Treat Inflammatory Defect | |
|---|---|---|
| Adipocytes | Fibroblasts | |
| Impaired early myeloid cell recruitment |
↑ Stimulated lipolysis ↑ Cathelicidin (CAMP/LL37) |
↑ Chemokine expression (CCL2, CXCL1, CXCL2, IL8/CXCL8) |
| Persistent inflammation | ↓ Basal lipolysis ↑ Cathelicidin (CAMP/LL37) ↑ Anti-inflammatory adipokine expression (Adiponectin) ↓ Pro-inflammatory adipokine expression (CCL2, IL1, IL6, IL18, Leptin, TNFα) |
↓ Pro-inflammatory cytokine expression (IL1, IL6, IL8/CXCL8, TNFα) ↓ SASP |