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. 2021 Feb 15;10:624498. doi: 10.3389/fonc.2020.624498

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Copyright © 2021 Tran, Sullivan, Chan, Yin, Sun, Fang, Dugar, Zhou and Bae-Jump

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SPR965 induced endoplasmic reticulum (ER) stress in ovarian cancer cells. The Hey and SKOV3 cells were treated with SPR965 at different concentrations for 8 h. Reactive oxygen species (ROS) products were measured by DCFH-DA assay. SPR965 significantly increased the levels of ROS in both cell lines compared to the control cells (A). Western blotting results showed that SPR965 increased the expression of cellular stress-related proteins including PERK, Ero1, and Bip in both cell lines after treatment for 24 h (B). Immunohistochemistry results showed that SPR965 increased the expression of Bip in the ovarian tumors of KpB mice (C). The results are shown as the mean ± SD and are representative of three independent experiments. *p<0.05, **p<0.01.