Figure 1.

Coagulation factors are required for lymphoma formation in the brain. A: Network of co-expressed proteins in cerebrospinal fluid from cancer patients. Nodes (circles) of the network represent proteins, and the edges (purple lines) between two nodes indicate published evidence for co-expression. Nodes are colored on the basis of functional categories significantly enriched in Reactome pathway terms [false discovery rate (FDR), <0.05]. B: Tissue array of 100 diffuse large B-cell lymphomas in specified tissues. Immunohistochemistry of fibrinogen deposits in specified tissue array comprising 100 malignant diffuse large B-cell lymphomas. Representative fibrinogen-staining tissues from lymph node and brain are shown. Data are given as means ± SEM (B). GPCR, G protein-coupled receptors; IR, immunoreactivity.