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. 2021 Mar;191(3):454–462. doi: 10.1016/j.ajpath.2020.11.010

Figure 3.

Figure 3

Compositional analysis of type 1 and nondiabetic pancreata. Tissue types were identified, then quantified as a percentage of total tissue area or body weight. A and B: For tissue type area (A) and weight (B), green represents nondiabetic autoantibody negative (ND AAb–); orange, nondiabetic autoantibody positive (ND AAb+); purple, type 1 diabetes with insulin-positive islets (T1D INS+); and pink, type 1 diabetes without insulin-positive islets (T1D INS–). C: Images of pancreatic tissue stained for hematoxylin and eosin, insulin, glucagon, and trichrome from the tail region of Network for Pancreatic Organ Donors with Diabetes Case 6237, an 18-year-old white female with type 1 diabetes for 12 years at the time of death. Islets observed in ductal and other nonendocrine/nonexocrine tissue were devoid of contact with acinar cells. Individual differences are noted. n = 14 ND AAb– (A); n = 12 ND AAb– (B); n = 3 single ND AAb+ (A); n = 5 double ND AAb+ (A); n = 8 total ND AAb+ (A); n = 2 single ND AAb+ (B); n = 5 double ND AAb+ (B); n = 7 total ND AAb+ (B); n = 10 T1D INS+ (A); n = 8 T1D INS+ (B); n = 7 T1D INS– (A and B). ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, and ∗∗∗∗ P < 0.0001. Scale bars: 2 mm (C, top row); 100 μm (C, bottom row).