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5-Chloro-2-aminopyridines CDK9 inhibitors published by GenFleet therapeutics.
|
||
|---|---|---|
| Compound | 9 | 10 |
| R | H | Me |
| IC50 (nM) | ||
| CDK9/cyclin T1 | 0.93 | 1.27 |
| CDK2/cyclin A | 6850 | 2860 |
| CDK5/p25 | 6950 | 4640 |
| CDK7/cyclin H | 3700 | 1720 |
| Cytotoxicity* | 31 | 30 |
CDK: cyclin-dependent kinase; IC50: half maximal inhibitory concentration. *Average of 11 cell lines.
