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2-aminotriazines CDK9 inhibitors published by Bayer.
|
||
|---|---|---|
| Compound | 48 | 49 |
| R | 1,2-oxazol-3yl | 3,4-difluorobenzen-1yl |
| IC50 (nM) | ||
| CDK9 | 7 | 11 |
| CDK2 | 2000 | 1300 |
| Cytotoxicity* | 680 | 715 |
CDK: cyclin-dependent kinase; IC50: half maximal inhibitory concentration. *Average of six cell lines.
