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Flavonoids published by China Pharmaceutical University.
|
||
|---|---|---|
| Compound | 69 | 70 |
| R | 3,5-Dimethyl-1H-pyrazol-4-yl | Piperazin-1yl |
| R′ | Me | H |
| IC50 (nM) | ||
| CDK9 | 2 | 3 |
| CDK1 | 432 | ND |
| CDK2 | 910 | 1180 |
| CDK4 | 254 | ND |
| CDK7 | 56 | NAD |
| Cytotoxicity* | 1400 | 1800 |
CDK: cyclin-dependent kinase; IC50: half maximal inhibitory concentration; ND: not determined. *Average of 11 cell lines.
