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Chromones published by the Council of Scientific and Industrial Research.
| |||
|---|---|---|---|
| Compound | 71 | 72 | 73 |
| R | 2,6-Dichlorophenyl | 2,3,4,5,6-Tetrafluorophenyl | 3-Fluorophenyl |
| CDK9/T1 IC50 (nM) | 2 | 12 | 30 |
| CDK2/A IC50 (nM) | 16 | 608 | 466 |
| Cytotoxicity * IC50 (µM) | 12.2 | 10.4 | ND |
CDK: cyclin-dependent kinase; IC50: half maximal inhibitory concentration; ND: not determined. *Average of five cell lines.
