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Tetracyclic compounds published by AbbVie.
| Selected examples* | CDK9 IC50 (nM) | Cytotoxicity H929 IC50 (µM) | ||
|---|---|---|---|---|
| R | R′ | Rʺ | ||
| SO2Me | H | ethyl | 120 | 0.032 |
| CH2CON(Me)2 | H | ethyl | 60 | 0.008 |
| (2(hydroxymethy)pyrrolidin-1yl) -2-one-ethan-1yl | F | H | 51 | 0.008 |
CDK, cyclin-dependent kinase; IC50, half maximal inhibitory concentration. *From the corresponding general structure in Figure 16.
