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. 2021 Jan 25;11:613883. doi: 10.3389/fphar.2020.613883

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Copyright © 2021 Wang, Zhu, Ye, Wang, Dong, Chen, Wang, Fu, Wu and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protective effect of activated STAT3 in the viral myocarditis (A) The related proteins were measured by western blot (n = 4). **p < 0.01 vs control groups (NC and AG490 group), ^△ p < 0.05 vs CVB3 groups (CVB3 and AG490 + CVB3 group) (B) HE staining of myocardium (n = 4,200×) and cardiac pathological scores (n = 4) **p < 0.01vs control groups (NC and AG490 group), ^△ p < 0.05 vs CVB3 groups (CVB3 and AG490 + CVB3 group) (C) M-mode echocardiogram images and analysis of LVEF and LVFS in different groups (n = 3). **p < 0.01vs control groups (NC and AG490 group), ^△ p < 0.05 vs CVB3 groups (CVB3 and AG490 + CVB3 group) (D) Survival analysis of viral myocarditis mice. Survival proportions at day 7 were 100% for the NC group and AG490 group, 52% for the CVB3 group, 36% for the CVB3+AG490 group. **p < 0.01 vs control groups (NC and AG490 group), ^△ p < 0.05 vs CVB3 groups (CVB3 and AG490 + CVB3 group).