Table 2.
RAS peptides levels based on sensitivity analysis (*)
| RAS peptides levels at study inclusion (**) | All (n = 28) |
Survivors (n = 16) |
Non-survivors (n = 12) |
P value |
|---|---|---|---|---|
| Renin, pg/mL median (IQR) | 15.3 (6.1–79) | 13 (4.5–21.3) | 77.8 (10.5–256.4) | 0.04 |
| Angiotensin I, pg/mL, median (IQR) | 579 (408–1156) | 996 (579–1510) | 439 (400–541) | 0.03 |
| Angiotensin II, pg/mL, median (IQR) | 276 (217–752) | 584 (240–915) | 248 (209–301) | 0.04 |
| Angiotensin 1–7, pg/mL, median (IQR) | 221 (174–355) | 328 (214–510) | 212 (168–231) | 0.04 |
| Angiotensin I/Angiotensin II ratio, median (IQR) | 1.8 (1.2–2.6) | 1.5 (1.2–2.8) | 1.9 (1.3–2.4) | 0.86 |
| Angiotensin II/ Angiotensin 1–7 ratio, median (IQR) | 1.53 (0.8–2) | 1.7 (0.9–2) | 1.4 (0.6–1.6) | 0.2 |
*We performed a sensitivity analysis excluding 4 patients who were taking ACEi/ARBs at study inclusion
**Healthy reference ranges: renin: 1.5–20 pg/ml; Angiotensin I: median 42 [IQR: 30.5–87.3] pg/ml; Angiotensin II: 25.1 ± 5.2 pg/ml; Angiotensin (1–7): 21.0 ± 4.1 pg/ml. Direct plasma renin levels were determined by chemiluminescent immunoassay. Angiotensin compounds were measured by ELISA assay (Fine Biotech Co., Ltd)
P values were calculated by Mann–Whitney test, Chi-square test and Fisher exact test, as appropriate, with a significance level of 0.05. All statistical analyses were performed using SAS 9.4 software (SAS Institute Inc, Cary, NC, USA)