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. 2021 Mar 1;16:114. doi: 10.1186/s13023-021-01757-w

Table 1.

Red blood cell proteins influenced by hydroxyurea

Protein category Proteins
Antioxidants

Catalase

Thioredoxin peroxidase

Flavin reductase

Peroxiredoxin-2 isoform

Oxidoreductase Aldehyde dehydrogenase
Protein repair and degradation

Chaperonin containing TCP1 subunits

Proteasome

Membrane structure p55
Cytoskeletal

Anion exchanger band 3

Actin

Stomatin

Ankyrin

Protein 4.1

Tropomodulin

Glycolytic enzymes

Glyceraldehydes-3-phosphate dehydrogenase

Fructose-bisphosphate aldolase

Reticulocyte membrane receptors

Alpha 4 beta 1-integrin

CD36

Mature RBC membrane receptors

CD47

CD147

Other Carbonic anhydrase