Table 5.
KEGG pathways enriched in murine diaphragms between 10 and 15 dpi
| ID | Description | Gene ratio (%) | Bg ratio (%) | Enrich. factor | q-value |
|---|---|---|---|---|---|
| ko00040 | Pentose and glucuronate interconversions | 3.75 | 0.51 | 7.35 | 0 |
| ko00260 | Glycine, serine and threonine metabolism | 4.13 | 0.57 | 7.21 | 0 |
| ko00983 | Drug metabolism-other enzymes | 4.69 | 0.73 | 6.38 | 0 |
| ko04610 | Complement and coagulation cascades | 9.19 | 1.14 | 8.03 | 1.36E−31 |
| ko00140 | Steroid hormone biosynthesis | 8.63 | 1.12 | 7.71 | 1.68E−28 |
| ko00053 | Ascorbate and aldarate metabolism | 3.75 | 0.39 | 9.73 | 2.12E−14 |
| ko00380 | Tryptophan metabolism | 3.94 | 0.57 | 6.88 | 1.46E−11 |
| ko00830 | Retinol metabolism | 9.01 | 1.19 | 7.54 | 3.64E−11 |
| ko05204 | Chemical carcinogenesis | 8.44 | 1.27 | 6.65 | 4.65E−11 |
| ko00120 | Primary bile acid biosynthesis | 2.45 | 0.20 | 12.25 | 5.01E−11 |
| ko00982 | Drug metabolism-cytochrome P450 | 6.00 | 0.93 | 6.43 | 9.06E−11 |
| ko00980 | Metabolism of xenobiotics by cytochrome P450 | 5.63 | 0.93 | 6.03 | 9.06E−11 |
| ko03320 | PPAR signaling pathway | 5.44 | 1.13 | 4.804136 | 1.43E−10 |
| ko04146 | Peroxisome | 5.07 | 1.06 | 4.788544 | 6.56E−10 |
| ko00071 | Fatty acid degradation | 3.75 | 0.66 | 5.688697 | 1.26E−08 |
| ko00860 | Porphyrin and chlorophyll metabolism | 3.19 | 0.55 | 5.82445 | 2.38E−07 |
| ko00591 | Linoleic acid metabolism | 3.38 | 0.65 | 5.22 | 6.13E−07 |
| ko00590 | Arachidonic acid metabolism | 4.50 | 1.16 | 3.89 | 1.17E−06 |
| ko00270 | Cysteine and methionine metabolism | 3.19 | 0.63 | 5.03 | 3.31E−06 |
| ko00500 | Starch and sucrose metabolism | 3.38 | 0.76 | 4.45 | 1.07E−05 |
| ko04976 | Bile secretion | 3.56 | 0.88 | 4.03 | 2.58E−05 |
| ko01040 | Biosynthesis of unsaturated fatty acids | 2.25 | 0.36 | 6.24 | 3.02E−05 |
| ko04950 | Maturity onset diabetes of the young | 2.06 | 0.32 | 6.38 | 7.86E−05 |
| ko01230 | Biosynthesis of amino acids | 3.94 | 1.22 | 3.23 | 0.000322 |
| ko00630 | Glyoxylate and dicarboxylate metabolism | 2.06 | 0.37 | 5.53 | 0.000435 |
| ko00340 | Histidine metabolism | 1.88 | 0.32 | 5.80 | 0.000786 |
| ko00220 | Arginine biosynthesis | 1.69 | 0.26 | 6.46 | 0.000854 |
| ko00770 | Pantothenate and CoA biosynthesis | 1.50 | 0.22 | 6.70 | 0.002209 |
| ko00350 | Tyrosine metabolism | 2.25 | 0.52 | 4.31 | 0.002898 |
| ko00410 | beta-Alanine metabolism | 1.88 | 0.40 | 4.71 | 0.006635 |
KEGG pathway analysis identified pathways over-represented in T. spiralis-infected mouse diaphragms (q-value < 0.01) between 10 and 15 dpi. Downregulated genes that were differentially expressed more than twofold were utilized as input. The DEGs corresponding to every enriched KEGG pathway are shown in Additional file 4: Table S4
PPAR Peroxisome proliferator-activated receptor, CoA coenzyme A; for other abbreviations, see Table 4