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. 2021 Mar 1;9:15. doi: 10.1186/s40364-021-00265-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Dissection and clustering of AML patient BM cells and healthy donor BM cells. a The UMAP projection of BM cells from 16 AML patients and 4 healthy donors, showing the formation of 22 main clusters, including 3 for T/NK cells (Cluster 0, Cluster 3, and Cluster 17), 3 for B lineage (Cluster 12, Cluster 14, and Cluster 16), 3 for mature myeloid lineage (Cluster 1, Cluster 11, and Cluster 20), 3 for erythroid lineage (Cluster 8, Cluster 18, and Cluster 19), 9 for SP-like cells (Cluster 2, Cluster 4, Cluster 5, Cluster 6, Cluster 7, Cluster 9, Cluster 10, Cluster 13, and Cluster 15), and 1 for non-hematopoietic stromal cells (Cluster 21). Each dot represents to one single cell, and is colored according to cell cluster. b CD3E, CD4, CD8A, CD1C, CD14, NCAM1, and CD79B-expressing (expression value > 0) of across 36,477 BM-derived cells illustrated in UMAP plots. c Histogram of cell-type fractions for each AML patient and healthy donors’ BM cells, colored based on cell type