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. 2021 Mar 1;9:15. doi: 10.1186/s40364-021-00265-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Dissection and clustering of DC-like cells in AML patients and healthy donors. a UMAP plot of DC-like cells from Fig. 1a-represented DC cluster. These DC-like cells can be divided into 5 subsets. b Expression of DC-related genes across the transcriptionally defined DC clusters. c Dot plot of select canonical DC-related genes (cDC1: CLEC9A, ANPEP, and FBXO27; cDC2: CLEC12A, CLEC10A, SIRPA, and DENND3; pDC: IL3RA and JCHAIN) differentially expressed between different DC subsets. d Proportion of 5 DC subsets in total DC cells in each AML patient or healthy donor. Only samples of containing ≥10 DC-like cells were represented. e Dot plot of differentially expressed co-inhibitory and co-stimulation molecule genes. f Dot plot of differentially expressed cytokine genes. g The Kaplan-Meier overall survival curves of TCGA AML patients grouped by specific DC subset (CD206⁺ DC and CX3CR1⁺ DC) gene sets and DC-related genes (TGFB1, MRC1, CLEC7A, ITGAX, ITGB2, CX3CR1, CCL22, and TNFSF8). + represents censored observations, and P value was calculated by multivariate Cox regression